N-[1, (1-1) -dialkyloxy] - and N- [1, (1-1) -dialkenyloxy]- alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor

阅读量:

15

作者:

DA EppsteinPL FelgnerTR GadekGH JonesRB Roman

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摘要:

This invention relates to compounds of the formula ##STR1## or an optical isomer thereof wherein R 1 and R 2 are the same or different and are an alkyl or alkenyl group of 6 to 24 carbon atoms; R 3 , R 4 and R 5 are the same or different and are alkyl of 1 to 8 carbon atoms, aryl, aralkyl of 7 to 11 carbon atoms, or when two or three of R 3 , R 4 , and R 5 are taken together to form quinuclidino, piperidino, pyrrolidino, or morpholino, n is 1 to 8; and X is a pharmaceutically acceptable anion.

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DOI:

US5550289 A

被引量:

236

年份:

1996

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1999
被引量:18

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