Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease.
摘要:
Microglial phagocytosis is critical for CNS homeostasis. Lucin etal. demonstrate that the autophagy protein beclin 1 is required for efficient phagocytosis and is reduced in microglia during Alzheimer's disease. Beclin 1 regulates phagocytic efficiency by facilitating phagocytic receptor recycling.
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关键词:
AUTOPHAGY GENE EMBRYONIC-DEVELOPMENT RETROGRADE TRANSPORT GLUTAMATE-RECEPTOR PARKINSON DISEASE TRANSGENIC MICE TYRO-3 FAMILY MOUSE MODEL PATHOLOGY PROTEIN
DOI:
10.1016/j.neuron.2013.06.046
被引量:
年份:
2013



















































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