TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model.
摘要：
TREM2 acts in microglia as a sensor for a wide array of lipids that are associated with β-amyloid accumulation and neuronal loss. The TREM2 mutation that has recently been identified as a risk factor for Alzheimer's disease attenuates microglial detection of damage-associated lipids, providing a mechanistic basis for the genetic association.
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10.1016/j.cell.2015.01.049
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2015
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来源期刊
Cell
12 March 2015
引用走势
2018
被引量：115
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