Apoptosis by death factor.
摘要：
Fas ligand (FasL), a cell surface molecule belonging to the tumor necrosis factor family, binds to its receptor Fas, thus inducing apoptosis of Fas-bearing cells. Various cells express Fas, whereas FasL is expressed predominantly in activated T cells. In the immune system, Fas and FasL are involved in down-regulation of immune reactions as well as in T cell-mediated cytotoxicity. Malfunction of the Fas system causes lymphoproliferative disorders and accelerates autoimmune diseases, whereas its exacerbation may cause tissue destruction.
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关键词：
Animals Humans Membrane Glycoproteins Receptors, Tumor Necrosis Factor Antigens, CD95 Ligands Signal Transduction Apoptosis Fas Ligand Protein
DOI：
10.1016/S0092-8674(00)81874-7
被引量：
年份：
1997
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