Subcellular distribution of gamma-hydroxybutyrate binding sites in rat brain principal localization in the synaptosomal fraction.

阅读量:

30

作者:

M MaitreJF RumignyC CashP Mandel

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摘要:

γ-Hydroxybutyrate binding sites, first described on crude membranes from rat brain, have been further studied on subcellular fractions. The nerve ending fraction (fraction C) exhibits the maximal capacity for GHB binding. The two classes of binding sites (high and low affinities) described for the crude membrane preparation are enriched in this synaptosomal fraction. This result is further evidence in favor of a role for GHB as a neurotransmitter or neuromodulator in rat brain.

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DOI:

10.1016/0006-291X(83)91289-5

被引量:

201

年份:

1983

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1996
被引量:21

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