摘要：

The effects of the new GABA_B antagonist, CGP 35348 (3-aminopropane-diethoxymethylphosphinic acid), on rat striatal dopamine synthesis and the increases thereof, caused by (–)-baclofen, <img src="/content/R32G00W441724465/xxlarge947.gif" alt="gamma" align="MIDDLE" border="0">-butyrolactone (GBL), and HA 966 (3-amino-l-hydroxypyrrolid-2-one), were investigated. CGP 35348 did not alter dopamine synthesis on its own up to the highest dose tested (500 mg/kg i.p.). However, it antagonized the increase elicited by 50 mg/kg s. c. (–)-baclofen at doses above 100 mg/kg i. p.; at 500 mg/kg i. p. this antagonism disappeared within about 6 h of interval between the administration of the compound and (–)-baclofen. CGP 35348 also clearly and significantly attenuated the effects of graded doses of GBL and HA 966 at 500 mg/kg i. p., but was unable to alter the responses elicited by 0.3 mg/kg i. p. haloperidol or 10 mg/kg i. p. tetrabenazine. This indicates that the compound did not generally

展开