Production of interferons by dendritic cells, plasmacytoid cells, natural killer cells, and interferon-producing killer dendritic cells
摘要：
The capacity of mouse spleen conventional dendritic cells (cDCs) and plasmacytoid dendritic cells (pDCs) to produce interferon-gamma (IFN-gamma) or IFN-alpha was assessed, and compared with that of natural killer (NK) cells and the recently identified interferon-producing killer dendritic cells (IKDCs), both of which are frequent contaminants in DC preparations. Fully developed cDCs or pDCs, if free of NK cells or IKDCs, showed little capacity for IFN-gamma production. However, an early developmental form of the CD4-8+ cDC subtype, and the Ly6C- Ly49Q- pDC subtype, both were able to produce moderate amounts of IFN-gamma, although less than IKDCs. In response to toll-like receptor 9 stimuli, both the Ly6C+ Ly49Q+ and the Ly6C- Ly49Q- pDC subtypes were effective producers of IFN-alpha. However, IKDCs, which efficiently produced IFN-gamma and showed immediate cytotoxicity on NK target cells, did not produce IFN-alpha under these conditions.
展开
关键词：
DOI：
10.1182/blood-2006-05-015354
被引量：
年份：
2007
Elsevier
Semantic Scholar
万方医学
dx.doi.org
Cell Press
查看更多
Europe PMC
NCBI
NCBI
AACR
ResearchGate
(全网免费下载)
ResearchGate
EBSCO
Citeseer
(全网免费下载)
deepdyve.com
jacionline.org
burnet.edu.au
mendeley.com
bloodjournal.org
(全网免费下载)
journal.9med.net
cghjournal.org
bloodjournal.org
bloodjournal.hematologylibrary.org
bloodjournal.hematologylibrary.org
(全网免费下载)
frontiersin.org
jem.rupress.org
ResearchGate
(全网免费下载)
Citeseer
(全网免费下载)
bloodjournal.hematologylibrary.org
(全网免费下载)
bloodjournal.org
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
