Click Chemistry: Diverse Chemical Function from a Few Good Reactions

Examination of nature's favorite molecules reveals a striking preference for making carbon–heteroatom bonds over carbon–carbon bonds—surely no surprise ...

Hartmuth C. Kolb Dr，M. G. Finn Prof，K. Barry Sharpless Prof - 《Angewandte Chemie International Edition》

The growing impact of click chemistry on drug discovery

Click chemistry, a modular approach based on highly reliable chemical transformations, is being applied in all aspects of drug discovery, ranging from lead...

HC Kolb，KB Sharpless - 《Drug Discovery Today》

ChemInform Abstract: Click Chemistry: Diverse Chemical Function from a Few Good Reactions

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a Chem...

HC Kolb，MG Finn，KB Sharpless - 《Cheminform》

Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo.

Glycomics is emerging as a new field for the biology of complex glycoproteins and glycoconjugates. The lack of versatile glycan-labeling methods has presen...

M Sawa，Hsu, TL，T Itoh，... - 《Proceedings of the National Academy of Sciences of the United States of America》

Carbohydrate microarrays — a new set of technologies at the frontiers of glycomics

Carbohydrate microarray technologies are new developments at the frontiers of glycomics. Results of 'proof of concept' experiments with carbohydrate-bindin...

T Feizi，F Fazio，W Chai，... - 《Curr Opin Struct Biol》

Antibiotic optimization via in vitro glycorandomization

In nature, the attachment of sugars to small molecules is often used to mediate targeting, mechanism of action and/or pharmacology. As an alternative to pa...

F Xun，C Albermann，J Jiang，... - 《Nature Biotechnology》

Polytriazoles as copper(I)-stabilizing ligands in catalysis

Polytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes. The C3-symmetric derivative, TBTA, was shown to be a powerf...

TR Chan，R Hilgraf，KB Sharpless，... - 《Organic Letters》

CuI-Catalyzed Alkyne—Azide “Click” Cycloadditions from a Mechanistic and Synthetic Perspective

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a Chem...

Victoria D. Bock，Henk Hiemstra，Jan H. van Maarseveen - 《Cheminform》

Polytriazoles as Copper(I)-Stabilizing Ligands in Catalysis

Polytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes. The C3-symmetric derivative, TBTA, was shown to be a powerf...

Timothy，R.，Chan，... - 《Organic Letters》

CuI-Catalyzed Alkyne–Azide “Click” Cycloadditions from a Mechanistic and Synthetic Perspective

CuI-catalyzed alkyne–azide cycloaddition provides 1,4-disubstituted 1,2,3-triazoles with such efficiency and scope that the transformation has been descri...

Victoria D. Bock，Henk Hiemstra，Jan H. van Maarseveen - 《European Journal of Organic Chemistry》