Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors
摘要：
The Rac guanosine 5′-triphosphate (GTP)-binding proteins regulate oxidant production by phagocytic leukocytes. Two Ste20-related p21-activated kinases (PAKs) were identified as targets of Rac in human neutrophils. Activity of the 65-and 68-kilodalton PAKs was rapidly stimulated by chemoattractants acting through pertussis toxin-sensitive heterotrimeric GTP-binding proteins (G proteins). Native and recombinant PAKs phosphorylated the p47$^{phox}$ reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase component in a Rac-GTP-dependent manner. The action of PAKs during phagocyte activation by G protein-coupled pathways may contribute to regulation of NADPH oxidase activity.
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关键词：
Neutrophil nadph oxidase Activation Phosphorylation Gtp. Translocation Stimulation Requirement Components
DOI：
10.1126/science.7618083
被引量：
年份：
1995
掌桥科研
Semantic Scholar
万方医学
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