Small organic molecule regulators of cell proliferation
申请(专利)号：
CA20012404413
申请日期：
2001-03-30
公开/公告号：
CA2404413A1
公开/公告日期：
2001-10-11
申请(专利权)人：
CURIS, INC.
被引量：
摘要：
The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33 . In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.
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