OPTIMIZATION OF SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) OF REPAGLINIDE USING D-OPTIMAL MIXTURE EXPERIMENTAL DESIGN

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Background : Hepatitis B virus (HBV) and hepatitis C virus (HCV) share common mode of transmission and both are able to induce a chronic infection. Dual HBV/HCV chronic confection is a fairly frequent occurrence, especially in high endemic areas and among individuals at high risk of parenterally transmitted infections. The intracellular interplay between HBV and HCV has not yet been sufficiently clarified, also due to the lack of a proper in vitro cellular model. Dual HBV/HCV infection has been associated to a severe course of the liver disease and to a high risk of developing hepatocellular carcinoma. This study aimed to determine seroprevalence of hepatitis C IgG anti bodies among known hepatitis B infected patients. Methods : This is a cross sectional study included HBV infected patients aged between (11-54) years old with mean 30.4 years old conducted in Talodi Hospital, South Kordofan, State, Sudan, during February to May 2014. We performed HCV serum marker, was detected by using commercially available enzyme-linked immunosorbent assay (ELISA) kit. Generated data were analyzed by using SPSS program (version11) Results: HCV IgG Ab was detected only in 1 (1.1%)from patient, and he was male. The mean age of the studied group was (30.4) their age range (11-54) years. There were 63 men (70%) and 27 women (30%), (n = 90). Conclusion : The seropositivity of HCV was low, similar to study done in Umdurman Maternity Hospital. Key words : Seroprevleance,Anti HCV,ELISA,Talodi hosptial

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DOI:

146

被引量:

7

年份:

2013

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2013
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