Liver‐specific Deletion of Protein Tyrosine Phosphatase (PTP) 1B Improves Endothelial Dysfunction and Cardiovascular Alterations Associated with Obesity in mice
摘要：
Obesity is tightly associated with insulin resistance (IR) and endothelial dysfunction. It is suggested that hepatic IR is sufficient to promote progression to cardiovascular disease. We showed recently that specific deletion of liver PTP1B (L-PTP1B), a negative regulator of insulin receptor, improves whole body glucose and lipid homeostasis. Thus, we propose to investigate the impact of these improvements in L-PTP1Bmice, on cardiovascular function in the context of diet-induced obesity.
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DOI：
10.1096/fasebj.26.1_supplement.526.5
被引量：
年份：
2012
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