PtdIns5P: News and views of its appearance, disappearance and deeds
摘要：
Accumulated evidence indicates that PtdIns5P, one of the seven phosphoinositides, found now to be constitutively present in yeast, plants and metazoa, serves as a signaling molecule to modulate pleiotropic cellular functions in both the nucleus and the cytoplasm. The enzymatic routes in biogenesis of basal PtdIns5P have remained incompletely understood. The role for candidate kinase \\{PIKfyve\\} that is principally involved in PtdIns(3,5)P2 production, has been questioned. In this review article we scrutinize the past obstacles that prevented the definitive implication of \\{PIKfyve\\} in PtdIns5P biosynthesis from PtdIns and focus on the recent pharmacological and genetic advancements that now make this conclusion well supported. We further summarize our current knowledge of the diverse stimuli modulating PtdIns5P levels, binding partners and regulated cellular process, with particular reference to the available mechanistic insights for the relevant signaling pathways.
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关键词：
<!-- Tag Not Handled --><keyword id=k0005>PtdIns5P <!-- Tag Not Handled --><keyword id=k0010>PIKfyve <!-- Tag Not Handled --><keyword id=k0015>MTM/MTMRs <!-- Tag Not Handled --><keyword id=k0020>PI4-phosphatases <!-- Tag Not Handled --><keyword id=k0025>PIP4-kinases <!-- Tag Not Handled --><keyword id=k0030>Insulin-regulated glucose transport <!-- Tag Not Handled --><keyword id=k0035>Actin cytoskeleton remodeling <!-- Tag Not Handled --><keyword id=k0040>Membrane trafficking <!-- Tag Not Handled --><keyword id=k0045>Stress responses <!-- Tag Not Handled --><keyword id=k0055>Akt
DOI：
10.1016/j.abb.2013.07.023
被引量：
年份：
2013
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