ChemInform Abstract: A STUDY OF CHEMICAL CARCINOGENESIS. 57. SYNTHESIS AND MUTAGENICITY OF DIHYDRODIOL METABOLITES OF BENZO(B)FLUORANTHENE

来自 Wiley

阅读量:

48

作者:

S AminN HussainH BrielmannSS Hecht

展开

摘要:

The syntheses of the two major hepatic microsomal dihydrodiol metabolites of the environmental carcinogen, benzo[b]fluoranthene, are described. 1,2-Dihydro-1,2-dihydroxybenzo[b]fluoranthene was prepared from 11H-benzo[b]fluorene-11-carboxylic acid. The key intermediate was 1-oxo-1,2,3,3a-tetrahydrobenzo[b]fluoranthene which was prepared by regiospecific cyclization of 11H-benzo[b]fluorene-11-propionic acid chloride. 11,12-Dihydro-11,12-dihydroxybenzo[b]fluoranthene was synthesized from 2-methylfluoranthene via 12-oxo-9,10,11,12-tetrahydrobenzo[b]fluoranthene. Both dihydrodiols were mutagenic toward Salmonella typhimurium TA 100, but their activities were less than that of benzo[b]fluoranthene.

展开

DOI:

10.1002/chin.198435198

被引量:

1071

年份:

1984

通过文献互助平台发起求助,成功后即可免费获取论文全文。

相似文献

参考文献

引证文献

来源期刊

Cheminform
1984/08/28

引用走势

1991
被引量:64

辅助模式

0

引用

文献可以批量引用啦~
欢迎点我试用!

引用