DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells.
摘要:
Dendritic cells (DC) capture microorganisms that enter peripheral mucosal tissues and then migrate to secondary lymphoid organs, where they present these in antigenic form to resting T cells and thus initiate adaptive immune responses. Here, we describe the properties of a DC-specific C-type lectin, DC-SIGN, that is highly expressed on DC present in mucosal tissues and binds to the HIV-1 envelope glycoprotein gp120. DC-SIGN does not function as a receptor for viral entry into DC but instead promotes efficient infection in trans of cells that express CD4 and chemokine receptors. We propose that DC-SIGN efficiently captures HIV-1 in the periphery and facilitates its transport to secondary lymphoid organs rich in T cells, to enhance infection in trans of these target cells.
展开
关键词:
Humans Lymphoid Tissue Lymph Nodes Mucous Membrane Dendritic Cells CD4-Positive T-Lymphocytes Rectum Uterus Cervix Uteri Cells, Cultured
DOI:
10.1016/S0092-8674(00)80694-7
被引量:
年份:
2000


























































通过文献互助平台发起求助,成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
来源期刊
引用走势
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用!