Foxp3 programs the development and function of CD4+CD25+ regulatory T cells.
摘要：
CD4+CD25+ regulatory T cells are essential for the active suppression of autoimmunity. Here we report that the forkhead transcription factor Foxp3 is specifically expressed in CD4+CD25+ regulatory T cells and is required for their development. The lethal autoimmune syndrome observed in Foxp3-mutant scurfy mice and Foxp3-null mice results from a CD4+CD25+ regulatory T cell deficiency and not from a cell-intrinsic defect of CD4+CD25- T cells. CD4+CD25+ regulatory T cells rescue disease development and preferentially expand when transferred into neonatal Foxp3-deficient mice. Furthermore, ectopic expression of Foxp3 confers suppressor function on peripheral CD4+CD25- T cells. Thus, Foxp3 is a critical regulator of CD4+CD25+ regulatory T cell development and function.
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关键词：
CD4-Positive T-Lymphocytes Animals Mice DNA-Binding Proteins Receptors, Interleukin-2 Gene Targeting Down-Regulation Female Forkhead Transcription Factors
DOI：
10.1038/ni904
被引量：
年份：
2003
Taylor & Francis
BMJ
Nature
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