The role of alkylphosphocholines in retinal Müller glial cell proliferation.
摘要：
Alkylphosphocholines (APCs) are investigated for their effect on Müller glial cell proliferation and F-actin stress fiber distribution in vitro.Müller cells were incubated with APCs (C18:1-PC and C22:1-PC) +/- fetal calf serum. Proliferation was assessed by BrdU labeling and with the tetrazolium dye-reduction assay. Toxicity was measured using the trypan blue exclusion assay. The distribution of F-actin stress fibers was determined using FITC-phalloidin staining.APCs are effective inhibitors of human and rat Müller glial cell proliferation and hypoxia-induced up-regulation of F-actin stress fibers in vitro in non-toxic concentrations.APCs might prevent intraretinal changes as a result of serum stimulation and hypoxia following retinal detachment.
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DOI：
10.1080/02713680801956460
被引量：
年份：
2008
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