Targeting Protein Tyrosine Phosphatases for Anticancer Drug Discovery
摘要：
Protein tyrosine phosphatases (PTPs) are a diverse family of enzymes encoded by 107 genes in the human genome. Together with protein tyrosine kinases (PTKs), PTPs regulate various cellular activities essential for the initiation and maintenance of malignant phenotypes. While PTK inhibitors are now used routinely for cancer treatment, the PTP inhibitor development field is still in the discovery phase. In this article, the suitability of targeting PTPs for novel anticancer drug discovery is discussed. Examples are presented for PTPs that have been targeted for anticancer drug discovery as well as potential new PTP targets for novel anticancer drug discovery.
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DOI：
10.2174/138161210791209027
被引量：
年份：
2010
国家科技图书文献中心
(权威机构)
万方医学
掌桥科研
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