Synthesis and antitumor activity of some novel hydrazide, 1,2‐dihydropyridine, chromene, and benzochromene derivatives

来自 EBSCO

阅读量：

作者：

展开

摘要：

2-Cyano-N′-[1-(substitutedphenyl)ethylidene]acetohydrazide 2a–c were obtained via reaction of acetophenone derivatives 1a–c with cyanoacetic acid hydrazide. The hydrazidehydrazone derivative 2a underwent a novel series of heterocyclization reactions via its reaction with aromatic aldehydes and/or arylidenemalononitriles to produce arylidene and dihydropyridine derivatives 3,5a–l, respectively. Structures of the newly synthesized compounds were confirmed by elemental analyses, IR, 13C-NMR, 1H-NMR and mass spectral data. All the newly synthesized compounds were evaluated for their in-vitro antitumor activity against Ehrlich Ascities Carcinoma (EAC) cells. Some of them showed interesting cytotoxic activity compared with Doxorubicin (CAS 23214-92-8) as a reference drug. J. Heterocyclic Chem., (2011).

展开

关键词：

3,5-dibromo-1,2,4-triazole o-quinone methides naphtho[1,2-e][1,2,4]triazolo[5,1-b][1,3]oxazines Mannich bases

DOI：

10.1002/jhet.829

被引量：

年份：

2012