Free radical generation by early glycation products: A mechanism for accelerated atherogenesis in diabetes
摘要：
Non-enzymatic glycation of reactive amino groups in model proteins increased the rate of free radical production at physiologic pH by nearly fifty-fold over non-glycated protein. Superoxide generation was confirmed by electron paramagnetic resonance measurements with the spin-trap phenyl-t-butyl-nitrone. Both Schiff base and Amadori glycation products were found to generate free radicals in a ratio of 1:1.5. Free radicals generated by glycated protein increased peroxidation of membranes of linoleic/arachidonic acid vesicles nearly 2-fold over control, suggesting that the increased glycation of proteins in diabetes may accelerate vascular wall lipid oxidative modification.
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关键词：
Humans Cell Membrane Arteriosclerosis Free Radicals Diabetes Mellitus Hyperglycemia Diabetes Complications Cyclic N-Oxides Schiff Bases Nitroblue Tetrazolium
DOI：
10.1016/S0006-291X(05)80875-7
被引量：
年份：
1990
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