Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by α5 subunit-containing γ-aminobutyric acid type A receptors
摘要：
The principal inhibitory neurotransmitter in the mammalian brain, γ-aminobutyric acid (GABA), is thought to regulate memory processes by activating transient inhibitory postsynaptic currents. Here we describe a nonsynaptic, tonic form of inhibition in mouse CA1 pyramidal neurons that is generated by a distinct subpopulation of GABA type A receptors ( GABA A Rs). This tonic inhibitory conductance is predominantly mediated by α5 subunit-containing GABA A Rs (α 5 GABA A Rs) that have different pharmacological and kinetic properties compared to postsynaptic receptors. GABA A Rs that mediate the tonic conductance are well suited to detect low, persistent, ambient concentrations of GABA in the extracellular space because they are highly sensitive to GABA and desensitize slowly. Moreover, the tonic current is highly sensitive to enhancement by amnestic drugs. Given the restricted expression of α 5 GABA A Rs to the hippocampus and the association between reduced α 5 GABA A R function and improved memory performance in behavioral studies, our results suggest that tonic inhibition mediated by α 5 GABA A Rs in hippocampal pyramidal neurons plays a key role in cognitive processes.
展开
关键词：
Animals Mice, Inbred C57BL Mice, Knockout Humans Mice Cell Line Imidazoles Pyridines Protein Subunits Recombinant Proteins
DOI：
10.1073/pnas.0307231101
被引量：
年份：
2004
国家科技图书文献中心
(权威机构)
Semantic Scholar
掌桥科研
Semantic Scholar
(全网免费下载)
doi.org
查看更多
万方医学
dx.doi.org
NCBI
JSTOR
NCBI
Europe PMC
Pubmed Central
(全网免费下载)
NCBI
(全网免费下载)
Europe PMC
(全网免费下载)
Oxford Univ Press
JBC
adsabs.harvard.edu
ResearchGate
(全网免费下载)
ResearchGate
www.pnas.org
scienceopen.com
core.ac.uk
jgp.rupress.org
ajpregu.physiology.org
cghjournal.org
core.kmi.open.ac.uk
jpet.aspetjournals.org
bvsalud.org
mysciencework.com
SAGE
learnmem.cshlp.org
biochemsoctrans.org
pubfacts.com
discovery.dundee.ac.uk
embojnl.embopress.org
deepdyve.com
readcube.com
mendeley.com
jacionline.org
pnas.org
(全网免费下载)
jneurosci.org
frontiersin.org
onAcademic
钛学术
钛学术
(全网免费下载)
ntp.neuroscience.wisc.edu
(全网免费下载)
Semantic Scholar
(全网免费下载)
Europe PMC
(全网免费下载)
NCBI
(全网免费下载)
Pubmed Central
(全网免费下载)
ResearchGate
(全网免费下载)
pnas.org
(全网免费下载)
钛学术
(全网免费下载)
ntp.neuroscience.wisc.edu
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
引用走势
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
