Cisplatin induced mitochondrial DNA damage in dorsal root ganglion neurons.
摘要：
Cisplatin binds mitochondrial DNA and the resulting adducts were quantitated by a novel PCR method. Cisplatin binding in mtDNA is similar to nuclear DNA binding. Adducts inhibit mtDNA replication and transcription. Cisplatin induces mitochondrial degradation in vitro and in vivo.
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DOI：
10.1016/j.nbd.2010.11.017
被引量：
年份：
2011
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