摘要：

This invention features a compound of formula (I): R1 is aryl or heteroaryl; each of R2 and R4, independently, is H, halogen, CN, alkyl, ORa, or NRaRb; R3 is H, halogen, CN, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cyclyl, heterocyclyl, ORa, OC(O)Ra, OC(O)NRaRb, NRaRb, NRaC(O)Rb, NRaS(O)Rb, NRaS(O)2Rb, NRaC(O)NRbRc NRaC(S)NRbR~, NRaC(NRb)NRcRd, NRaC(O)ORb, S(O)NTRaRt, S(O)2NRSRb, S(O)Ra, S(O)2Ra, C(O)Ra, C(O)ORa, or C(O)NRaRl; R5 is H or alkyl; n is 0, 1, 2, 3, 4, 5, or 6; A is 0, S, S(O), S(O)2, or NW; B is N or CRC; X is0, S, S(O), S(O)2, NR, or C(O); Y is a covalent bond, C(O), C=NR a, O, S, S(O), S(O)2, or NW; Z is N or CH; each of U and V, independently, is N or CR; and W is 0, S, or NR'; in which each of Ra, Rb, Re, and Rd, independently, is H, alkyl, aryl, heteroaryl, cyclyl, or heterocyclyl; Re is H, alkyl, aryl, acyl, or sufonyl; and Rf is H, alkyl., aryl, acyl, sulfonyl, alkoxyl, amino, ester, amide, CN, or halogen. The compound is useful for treating an interleukin- 12 overproduction-related disorder.

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