Spatiotemporal organization and mechanosensory function of podosomes
摘要：
Podosomes are small, circular adhesions formed by cells such as osteoclasts, macrophages, dendritic cells, and endothelial cells. They comprise a protrusive actin core module and an adhesive ring module composed of integrins and cytoskeletal adaptor proteins such as vinculin and talin. Furthermore, podosomes are associated with an actin network and often organize into large clusters. Recent results from our laboratory and others have shed new light on podosome structure and dynamics, suggesting a revision of the classical core-ring model. Also, these studies demonstrate that the adhesive and protrusive module are functionally linked by the actin network likely facilitating mechanotransduction as well as providing feedback between these two modules. In this commentary, we briefly summarize these recent advances with respect to the knowledge on podosome structure and discuss force distribution mechanisms within podosomes and their emerging role in mechanotransduction.
展开
DOI：
10.4161/cam.28182
被引量：
年份：
2014
Taylor & Francis
国家科技图书文献中心
(权威机构)
掌桥科研
万方医学
Semantic Scholar
查看更多
dx.doi.org
NCBI
Europe PMC
NCBI
Europe PMC
(全网免费下载)
NCBI
(全网免费下载)
ResearchGate
EBSCO
repository.ubn.ru.nl
mysciencework.com
mendeley.com
core.ac.uk
onacademic.com
pubfacts.com
landesbioscience.com
doc.utwente.nl
jcs.biologists.org
narcis.nl
hdl.handle.net
deepdyve.com
学术范
(全网免费下载)
学术范
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
