Clinical testing of the radiosensitiser Ro-07-0582. I. Dose tolerance, serum and tumour concentrations
摘要：
Patients have been given single oral doses of the radiosensitiser Ro-07-0582 and serum concentrations have been attained in the range expected to be of value in radiosensitisation. Immediate gastrointestinal side effects appear to limit the dose to below 140 mg/kg but radiosensitising serum levels of approximately 200 μg/ml can be attained. Tolerance may be improved by giving anti-emetics and a more palatable preparation. Estimates of the concentration of Ro-07-0582 in tumour have ranged from 12 to 92% of the serum concentration at the time of determination.
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DOI：
10.1016/S0009-9260(76)80137-7
被引量：
年份：
1976
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