摘要：

This article presents a case study concerning a 15-year-old boy with severe prenatal and postnatal growth failure, sensorineural deafness, and mental retardation who had a homozygous partial deletion of the insulin-like growth factor I (IGF-I) gene. The authors mention that this patient had severe intrauterine growth retardation, providing direct evidence that IGF-I plays a critical part in human fetal growth, independently of growth hormone.

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