Arrested Differentiation, the Self-Renewing Memory Lymphocyte, and Vaccination
摘要：
Vaccination for persistent viral or bacterial infections must program the immune system for a lifelong need to generate antigen-specific effector lymphocytes. How the immune system does this is not known, but recent studies have shown that a subset of B lymphocytes, the germinal center B cell, is capable of self-renewal because it expresses a transcriptional repressor, BCL6, that blocks terminal differentiation. If a similar mechanism for arresting differentiation exists for long-lived, antigen-selected lymphocytes, a stem cell-like capacity for self-renewal could be the basis for the continual generation of effector lymphocytes from the memory pool. Understanding how to regulate the terminal differentiation of lymphocytes will improve immunotherapeutic approaches for chronic infectious diseases and cancer.
展开
关键词：
B-Lymphocytes Lymphocytes T-Lymphocytes Stem Cells Animals Humans DNA-Binding Proteins Receptors, Antigen Proto-Oncogene Proteins Transcription Factors
DOI：
10.1126/science.1062589
被引量：
年份：
2001
Springer
Wiley
掌桥科研
万方医学
Ingenta
查看更多
Europe PMC
NCBI
NCBI
JSTOR
AACR
ProQuest
ResearchGate
Citeseer
(全网免费下载)
EBSCO
EBSCO
jleukbio.org
embojnl.embopress.org
ganino.com
(全网免费下载)
mysciencework.com
bbmt.org
jimmunol.org
cghjournal.org
onAcademic
highbeam.com
haematologica.org
jem.rupress.org
go.galegroup.com
jacionline.org
sciencemag.org
bloodjournal.org
www.socolar.com
mendeley.com
biomedsearch.com
Citeseer
(全网免费下载)
ganino.com
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
来源期刊
引用走势
站内活动
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
