摘要：

OBJECTIVE: To explore the role of CD(47) and P-selectin in patients with COPD. METHODS: The blood plasma levels of CD(47) and P-selectin in 20 healthy volunteers (control group) and 35 patients with COPD in acute exacerbation and at stable stage were measured by flow cytometry. Platelet count was measured by hematology analyzer. SNK-q test and Pearson correlation analysis of the regression equation were used for statistics. RESULTS: The level of CD(47) in the COPD acute exacerbation group [(93 +/- 4)%] was significantly higher than that of the COPD stable group [(72 +/- 11)%] and that of the control group [(67 +/- 10)%], q = 11.26, 13.32, all P 0.05). The level of P-selectin in the acute exacerbation group [(35 +/- 11)%] was significantly higher than those of the stable group [(12 +/- 8)%] and the control group [(10 +/- 4)%] (q = 9.93, 12.19, all P 0.05). A significant positive correlation between CD(47) and P-selectin was observed in the acute exacerbation group(r = 0.77, P 0.05). CONCLUSIONS: The levels of CD(47) and P-selectin as markers of platelet activation increase significantly during AECOPD, which suggests that platelet activation exists in AECOPD and platelets as a type of inflammatory cells participate in the disease.

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