Succinyl hydroxamic acid, N-formyl-N-hydroxy amino carboxylic acid and succinic acid amide derivatives as metalloprotease inhibitors

阅读量:

17

申请(专利)号:

AU19950025722

申请日期:

1995-05-26

公开/公告号:

AU2572295A

公开/公告日期:

1995-12-21

申请(专利权)人:

BRITISH BIOTECH PHARMACEUTICALS LIMITED

发明人:

A MillerRP BeckettFM MartinM Whittaker

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被引量:

64

摘要:

A pharmaceutical or veterinary composition comprising a compound of formula I ##STR1## wherein X is a --CO.sub.2 H group and R. sub.1, R. sub. 2, R.sub.3, R.sub.4, R.sub.5 are as defined in the specification, or a salt, hydrate or solvate thereof, and a pharmaceutically or veterinarily acceptable excipient or carrier. A method of treatment of diseases or conditions mediated by MMPs in mammals, such as rheumatoid arthritis, osteoarthritis, periodontitis, gingivitis, corneal ulceration or tumour invasion by secondary means, by administering to the mammal an effective amount of the composition.

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