Succinyl hydroxamic acid, N-formyl-N-hydroxy amino carboxylic acid and succinic acid amide derivatives as metalloprotease inhibitors
申请(专利)号:
AU19950025722
申请日期:
1995-05-26
公开/公告号:
AU2572295A
公开/公告日期:
1995-12-21
申请(专利权)人:
BRITISH BIOTECH PHARMACEUTICALS LIMITED
被引量:
摘要:
A pharmaceutical or veterinary composition comprising a compound of formula I ##STR1## wherein X is a --CO.sub.2 H group and R. sub.1, R. sub. 2, R.sub.3, R.sub.4, R.sub.5 are as defined in the specification, or a salt, hydrate or solvate thereof, and a pharmaceutically or veterinarily acceptable excipient or carrier. A method of treatment of diseases or conditions mediated by MMPs in mammals, such as rheumatoid arthritis, osteoarthritis, periodontitis, gingivitis, corneal ulceration or tumour invasion by secondary means, by administering to the mammal an effective amount of the composition.
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