Mycobacterium tuberculosis phagosome
摘要：
The arrest of Mycobacterium tuberculosis phagosome maturation in infected macrophages is a phenomenon of dual significance both for the pathogenesis of tuberculosis and as a model system to study interference of microbes with membrane trafficking and organelle biogenesis in host cells. Among other factors, compartment-specialized regulators of vesicular trafficking and other parts of membrane fusion machinery are likely to play a role in these processes. Here we summarize the emerging view of mycobacterial phagosome maturation arrest in the context of the dynamic processes of intracellular membrane trafficking.
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关键词：
Mycobacterium tuberculosis Cells, Cultured GTP-Binding Proteins rab GTP-Binding Proteins rab5 GTP-Binding Proteins Membrane Proteins Cation Transport Proteins Microscopy, Confocal Cytokines Mycobacterium bovis
DOI：
10.1046/j.1365-2958.1999.01279.x
被引量：
年份：
2010
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