A Primitive T Cell-Independent Mechanism of Intestinal Mucosal IgA Responses to Commensal Bacteria
摘要：
The immunoglobulin A (IgA) is produced to defend mucosal surfaces from environmental organisms, but host defenses against the very heavy load of intestinal commensal microorganisms are poorly understood. The IgA against intestinal commensal bacterial antigens was analyzed; it was not simply "natural antibody" but was specifically induced and responded to antigenic changes within an established gut flora. In contrast to IgA responses against exotoxins, a significant proportion of this specific anti-commensal IgA induction was through a pathway that was independent of T cell help and of follicular lymphoid tissue organization, which may reflect an evolutionarily primitive form of specific immune defense.
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关键词：
Animals Mice, Inbred C57BL Mice B-Lymphocytes T-Lymphocytes Peritoneum Intestinal Mucosa Enterobacter cloacae Escherichia coli Bacterial Proteins
DOI：
10.1126/science.288.5474.2222
被引量：
年份：
2000
Taylor & Francis
BMJ
Semantic Scholar
dx.doi.org
NCBI
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