Aqueous nanoparticle suspensions for use in drug discovery
申请(专利)号:
PCT/US2010/055513
申请日期:
Nov 4, 2010
公开/公告号:
WO 2011057017 A1
申请(专利权)人:
国省代号:
WO
被引量:
摘要:
Methods for evaluating potential active agents are disclosed. A feed stock including a potential active agent and an amphiphilic polymer in a water-miscible solvent is provided, the potential active agent and polymer each being poorly water soluble. The feed stock is combined with an aqueous solution to produce a suspension of nanoparticles that include the potential active agent and the polymer. A liquid-phase assay is performed with an aliquot of the suspension to determine a pre-selected property of the potential active agent. In some embodiments, the polymer is a substituted dextran, such as dextran acetate, dextran propionate, dextran butyrate, dextran isobutyrate, or a mixture thereof. In certain embodiments, the amphiphilic polymer is a functionalized oxidized dextran with at least one oxidized group and an alkyl ester substituent selected from acetate, propionate, butyrate, isobutyrate, and mixtures thereof. In some embodiments, the polymer is a substituted cellulosic.
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