Molecular mimicry: frequency of reactivity of monoclonal antiviral antibodies with normal tissues.
摘要：
More than 600 monoclonal antiviral antibodies made against 11 different viruses were screened against 14 different organs from normal uninfected mice. Of these antiviral antibodies, 21, or approximately 3.5%, reacted with specific cells in these organs. Several of these antibodies were of the multiple-organ-reactive type and recognized antigens in more than one organ. It was concluded that the reactivity of monoclonal antiviral antibodies with normal tissues is a common phenomenon.
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关键词：
Animals Mice, Inbred BALB C Mice Viruses Immunoglobulin G Immunoglobulin M Antibodies, Monoclonal Antibodies, Viral Antigens Organ Specificity
DOI：
10.1002/jmv.1890180111
被引量：
年份：
1986
Europe PMC
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NCBI
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Pubmed Central
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ResearchGate
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jvi.asm.org
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