RAPAMYCIN (AY-22, 989), A NEW ANTIFUNGAL ANTIBIOTIC
摘要：
Rapamycin is a new antifungal antibiotic produced by Streptomyces hygroscopicus NRRL 5491. It was isolated from the mycelium by solvent extraction, purified by silica gel column chromatography and crystallized as a colorless solid which melts at 183 approximately to 185 degrees C and has the empirical formula C56H89NO14. From its characteristic ultraviolet absorption spectrum rapamycin can be classified as a triene. It is highly active against various Candida species, especially Candida albicans. Its activity is compared with that of amphotericin B, candicidin and nystatin.
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关键词：
Animals Dogs Mice Rats Candidiasis Vaginal Diseases Polyenes Amphotericin B Nystatin Antibiotics, Antifungal
DOI：
10.7164/antibiotics.31.539
被引量：
年份：
1979
BMJ
doi.org
万方医学
Oxford Univ Press
NCBI
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