Composition for enhancing the administration of pharmacologically active agents
申请(专利)号:
US05/854404
申请日期:
19771123
公开/公告号:
US04168308A
公开/公告日期:
19790918
申请(专利权)人:
APOTEKSVARUCENTRALEN VITRUM AB
被引量:
摘要:
According to the invention, the parenteral administration of water- insoluble pharmacologically active agents is enhanced wherein the agents are administered in the lipoid phase of a carrier emulsion comprising a microemulsion of a finely dispersed lipoid in an aqueous phase. The lipoid preferably has a mean particle size below 1 micron. This makes it possible to administer water-insoluble agents in high concentrations, and thus a lower dose, whereby a rapid onset of the pharmacological effect is accompanied by a markedly reduced incidence of injury to body tissues.
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