Immunoregulatory T cells in tumor immunity.
摘要：
One mechanism of cancer immune evasion is the suppression of anti-tumor immunity by immunoregulatory T cells. Recent studies of these cells, especially CD4 +CD25 + T cells and NKT cells, have revealed molecular and cellular mechanisms of immunosuppression. Mouse studies have shown that either removing immunoregulatory T cells or blocking an immunoregulatory pathway induced by such cells unmasks natural tumor immunosurveillance and improves responses to cancer vaccines. Studies of the corresponding T-cell populations in human cancer patients support a similar role for immunoregulatory T cells in immunosuppression, implying that blocking immunoregulatory T-cell activity might improve the efficacy of tumor vaccines or the immunotherapy of cancer.
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关键词：
α-GalCer α- galactosylceramide α- galactosylceramide CTL cytotoxic T lymphocyte cytotoxic T lymphocyte CTLA-4 CTL-associated antigen 4 CTL-associated antigen 4 DC dendritic cell dendritic cell GITR glucocorticoid-induced TNF receptor glucocorticoid-induced TNF receptor
DOI：
10.1016/j.coi.2004.01.010
被引量：
年份：
2004
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