Straightforward Synthesis of Depsiphosphonopeptides via Mannich-Type Multicomponent Condensation

阅读量:

42

作者:

J XuY Gao

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摘要:

A straightforward method for the synthesis of depsiphosphonopeptides via a Mannich-type multicomponent condensation of simple starting materials, Such as benzyl carbamate, aldehydes, and 1-carbetboxyalkyl phosphorodichloridites, was developed. Compared to previous methods, our strategy provides a more efficient, convenient, and practical route for the preparation of depsiphosphonopeptides under mild reaction conditions with good yields. Such a strategy avoids the initial synthesis of 1-ammoalkylphosphonic acid or 1-aminoalkylphosphonous acid derivatives as starting materials.

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DOI:

10.1002/chin.200628179

被引量:

32

年份:

2006

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来源期刊

ChemInform
2006/07/11

引用走势

2007
被引量:6

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