Straightforward Synthesis of Depsiphosphonopeptides via Mannich-Type Multicomponent Condensation
摘要:
A straightforward method for the synthesis of depsiphosphonopeptides via a Mannich-type multicomponent condensation of simple starting materials, Such as benzyl carbamate, aldehydes, and 1-carbetboxyalkyl phosphorodichloridites, was developed. Compared to previous methods, our strategy provides a more efficient, convenient, and practical route for the preparation of depsiphosphonopeptides under mild reaction conditions with good yields. Such a strategy avoids the initial synthesis of 1-ammoalkylphosphonic acid or 1-aminoalkylphosphonous acid derivatives as starting materials.
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关键词:
depsiphosphonopeptides Mannich reactions multicomponent condensations peptides phosphonates phosphonopeptides
DOI:
10.1002/chin.200628179
被引量:
年份:
2006
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