摘要：

This study was carried out to assess sedative, anxiolytic and analgesic effect of oral clonidine (2 or 4 mgkg-1) in children. In a prospective randomised double blind trial, 75 children of 2-12 years received either oral clonidine 2 (group 2C) or 4 mgkg-1 (group 4C) or diazepam 0.2 mgkg-1 (group D) 90 minutes prior to minor surgeries. Perioperatively the level of sedation, quality of parental separation, mask acceptance and haemodynamics were recorded. Postoperative pain was assessed using Objective Pain Scale (OPS). OPS > 6 demanded rescue analgesic. Clonidine 4 mgkg-1 group had higher sedation score (2.77±0.42), compared to clonidine 2 mgkg- 1 group (2.39±0.63;p <0.05) and diazepam group (2.08±0.57; p <0.001). At 90 mins, sedation score of 3 was achieved 48%, 72% and 20% in 2C, 4C and D groups respectively. The difference of this proportion between 4C and D groups was 52% with confidence interval (CI) from 73% - 31% and the difference between 2C and D group was 28% with 95% CI of 53.6% to 2.4%. Parental separation and mask acceptance scores and number of patients with IV acceptance were higher with both clonidine groups compared to diazepam; there was no significant difference between two clonidine groups for the same. Rescue analgesics were required in 20% of clonidine group versus 96% of diazepam group patients; 52% of diazepam group required a repeat dose (p<0.001). The two clonidine groups showed a reduction in rescue analgesia requirement of 76% (96% in D and 20% each in 2C and 4C groups) with 95% CI of 93% and 59%.Incidence of postoperative hypotension was 8% with clonidine 4 mgkg-1. A single oral dose of clonidine 2 mgkg-1 can provide good anxiolysis and postoperative analgesia with minimum side effects.Keywords : Preanaesthetic medication, Clonidine, Alpha 2 agonists, Clonidine, Paediatric.

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