摘要：

PCT No. PCT/AU90/00556 Sec. 371 Date Aug. 12, 1991 Sec. 102(e) Date Aug. 12, 1991 PCT Filed Nov. 20, 1990 PCT Pub. No. WO91/07992 PCT Pub. Date Jun. 13, 1991.The present invention relates to the use of leukaemia inhibitory factor (LIF), alone or in combination with other cytokines such as interleukin-6 (IL-6) and/or transforming growth factor alpha (TGF alpha ) and/or fibroblast growth factor (FGF), to stimulate the proliferation and/or differentiation of mammalian satellite cells. The present invention also contemplates a method comprising myoblast transfer therapy whereby LIF, alone or in combination with other cytokines, is/are employed to proliferate and/or differentiate mammalian satellite cells into myoblasts. The present invention is also directed to a cell activating composition and a pharmaceutical composition comprising LIF alone or in combination with other cytokines to promote proliferation and/or differentiation of mammalian satellite cells in vitro and in vivo, respectively.

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