Mechanisms Establishing TLR4-Responsive Activation States of Inflammatory Response Genes
摘要：
Author Summary The innate immune response is a complex biological program that is configured to allow host cells to rapidly respond to infection and tissue injury. An essential feature of this response is the sequential activation of large numbers of genes that play roles in amplification of the initial inflammatory response, exert anti-microbial activities, and initiate acquired immunity. Here, we use a combination of genome-wide approaches to characterize the basal and activated states of promoters that drive the expression of genes that are turned on at immediate/early or late times in macrophages following their stimulation with a mimetic of bacterial infection. These studies identify genetically encoded features that establish basal levels of expression and distinct temporal profiles of signal-dependent gene activation required for effective immune responses. The general features of immediate/early and late genes defined by these studies are likely to be instructive for understanding how other high-magnitude, temporally orchestrated programs of gene expression are established.
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关键词：
Hematopoietic Stem Cells Cells, Cultured Macrophages Animals Humans Mice Inflammation Histone-Lysine N-Methyltransferase RNA Polymerase II Histones
DOI：
10.1371/journal.pgen.1002401
被引量：
年份：
2011
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