The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy
摘要：
Tumour development requires a combination of defects that allow nascent neoplastic cells to become self-sufficient for cell proliferation and insensitive to signals that normally restrain cell growth. Among the latter, evasion of programmed cell death (apoptosis) has proven to be critical for the development and sustained growth of many, perhaps all, cancers. Apoptotic cell death is regulated by complex interactions between pro-survival members and two subgroups of pro-apoptotic members of the B-cell lymphoma-2 (Bcl-2) protein family. In this invited review article, we reminisce on the discovery of Bcl-2, the first regulator of cell death identified, we discuss the mechanisms that control apoptotic cell death, focussing on how defects in this process promote the development and sustained growth of tumours and also affect their responses to anticancer therapeutics and, finally, we describe how current knowledge of the regulatory networks of apoptosis is exploited to develop novel approaches for cancer therapy.
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DOI：
10.1038/cdd.2011.17
被引量：
年份：
2011
Springer
Nature
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Nature
Wiley
EBSCO
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Semantic Scholar
万方医学
掌桥科研
dx.doi.org
NCBI
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NCBI
NCBI
Europe PMC
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Europe PMC
Oxford Univ Press
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ResearchGate
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ResearchGate
ProQuest
EBSCO
EBSCO
EBSCO
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