Biological inactivation of enkephalins and the role of enkephalin-dipeptidylcarboxypeptidase ("Enkephalinase") as neuropeptidase
摘要：
The weak and short-lasting biological activity of enkephalins can be ascribed to their rapid metabolism. Three types of well defined peptidase activities in CNS may account for the hydrolysis of the opioid pentapeptides : aminopeptidases, angiotensin-converting enzyme and enkephalin-dipeptidylcarboxypeptidase. The properties of these various enzyme activities are described and their possible involvement in the inactivation of synaptically-released enkephalins is discussed in the light of criteria proposed to identify "neuropeptidases".
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DOI：
10.1016/0024-3205(81)90182-X
被引量：
年份：
1981
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