Phagosome maturation during the removal of apoptotic cells: receptors lead the way.
摘要：
In metazoan organisms, cells undergoing apoptosis are rapidly engulfed and degraded by phagocytes. Defects in apoptotic-cell clearance result in inflammatory and autoimmune responses. However, little is known about how apoptotic-cell degradation is initiated and regulated and how different phagocytic targets induce different immune responses from their phagocytes. Recent studies in mammalian systems and invertebrate model organisms have led to major progress in identifying new factors involved in the maturation of phagosomes containing apoptotic cells. These studies have delineated signaling pathways that promote the sequential incorporation of intracellular organelles to phagosomes and have also discovered that phagocytic receptors produce the signals that initiate phagosome maturation. Here, we discuss these exciting new findings, focusing on the mechanisms that regulate the interactions between intracellular organelles and phagosomes.
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关键词：
Animals Dendritic Cells Drosophila Caenorhabditis elegans rab GTP-Binding Proteins rab5 GTP-Binding Proteins Phosphatidylinositol Phosphates Caenorhabditis elegans Proteins Drosophila Proteins Signal Transduction
DOI：
10.1016/j.tcb.2008.08.002
被引量：
年份：
2008
Elsevier
国家科技图书文献中心
(权威机构)
掌桥科研
万方医学
dx.doi.org
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