Transcription of the β-like globin genes and pseudogenes of the goat in a cell-free system
摘要：
We have examined the transcription in a cell-free system of all the members of a highly regulated gene family, the beta-like hemoglobin genes of the goat. These five genes, which code for embryonic, fetal, juvenile, and adult beta-globin proteins, are all transcribed to roughly the same extent in the in vitro system. In all cases initiation of transcription is accurate. However, two goat beta-globin pseudogenes, as well as several artificially constructed deletion mutants, are not transcribed in vitro. A common feature of the transcriptionally inactive genes is the lack of an AT-rich consensus sequence just upstream of the presumptive initiation site.
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关键词：
Animals Goats Cell-Free System DNA Restriction Enzymes DNA Globins Electrophoresis, Polyacrylamide Gel Base Sequence Mutation Transcription, Genetic
DOI：
10.1093/nar/9.17.4339
被引量：
年份：
1981
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