NALPs: a novel protein family involved in inflammation.
摘要：
A newly discovered family of cytoplasmic proteins--the NALPs--has been implicated in the activation of caspase-1 by the Toll-like receptors (TLRs) during the cell's response to microbial infection. Like the structurally related apoptotic protease-activating factor-1 (APAF-1), which is responsible for the activation of caspase-9, the NALP1 protein forms a large, signal-induced multiprotein complex, the inflammasome, resulting in the activation of pro-inflammatory caspases.
展开
关键词：
Humans Inflammation Macromolecular Substances Multiprotein Complexes Caspases Adaptor Proteins, Signal Transducing Proteins Membrane Glycoproteins Drosophila Proteins Receptors, Cell Surface
DOI：
10.1038/nrm1019
被引量：
年份：
2003
BMJ
Nature
Nature
(全网免费下载)
EBSCO
万方医学
查看更多
掌桥科研
Ingenta
dx.doi.org
Oxford Univ Press
NCBI
Europe PMC
ResearchGate
EBSCO
EBSCO
readcube.com
reproduction-online.org
ajpheart.physiology.org
science-open.com
scienceopen.com
www.socolar.com
mendeley.com
en.zl50.com
msb.embopress.org
jacionline.org
mysciencework.com
pubfacts.com
serval.unil.ch
onAcademic
Nature
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
