Highly Active Antiretroviral Therapy-Associated Metabolic Syndrome and Cardiovascular Risk
摘要：
The introduction of highly active antiretroviral therapy (HAART) has significantly modified the course of human immunodeficiency virus (HIV) disease, with longer survival and improved quality of life of HIV-infected subjects. However, HAART regimens, especially those including protease inhibitors, have been shown to cause in a high proportion of HIV-infected patients a metabolic syndrome (lipodystrophy/lipoatrophy, dyslipidemia, type 2 diabetes mellitus, insulin resistance) that may be associated with an increased risk of cardiovascular disease (coronary artery disease and stroke). A careful stratification of the cardiovascular risk and cardiovascular monitoring of patients under HAART is needed according to the most recent clinical guidelines.
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关键词：
human immunodeficiency virus highly active antiretroviral therapy metabolic syndrome cardiovascular disease
DOI：
10.1159/000093034
被引量：
年份：
2006
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