The human Y chromosome: a 43-interval map based on naturally occurring deletions
摘要：
A deletion map of the human Y chromosome was constructed by testing 96 individuals with partial Y chromosomes for the presence or absence of many DNA loci. The individuals studied included XX males, XY females, and persons in whom chromosome banding had revealed translocated, deleted, isodicentric, or ring Y chromosomes. Most of the 132 Y chromosomal loci mapped were sequence-tagged sites, detected by means of the polymerase chain reaction. These studies resolved the euchromatic region (short arm, centromere, and proximal long arm) of the Y chromosome into 43 ordered intervals, all defined by naturally occurring chromosomal breakpoints and averaging less than 800 kilobases in length. This deletion map should be useful in identifying Y chromosomal genes, in exploring the origin of chromosomal disorders, and in tracing the evolution of the Y chromosome.
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关键词：
Humans Y Chromosome Electrophoresis, Polyacrylamide Gel Chromosome Mapping Polymerase Chain Reaction Base Sequence Sequence Tagged Sites Molecular Sequence Data Genome, Human Gene Deletion
DOI：
10.1126/science.1439769
被引量：
年份：
1992
BMJ
万方医学
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