The Connectome of a Decision-Making Neural Network
摘要：
In order to understand the nervous system, it is necessary to know the synaptic connections between the neurons, yet to date, only the wiring diagram of the adult hermaphrodite of the nematode Caenorhabditis elegans has been determined. Here, we present the wiring diagram of the posterior nervous system of the C. elegans adult male, reconstructed from serial electron micrograph sections. This region of the male nervous system contains the sexually dimorphic circuits for mating. The synaptic connections, both chemical and gap junctional, form a neural network with four striking features: multiple, parallel, short synaptic pathways directly connecting sensory neurons to end organs; recurrent and reciprocal connectivity among sensory neurons; modular substructure; and interneurons acting in feedforward loops. These features help to explain how the network robustly and rapidly selects and executes the steps of a behavioral program on the basis of the inputs from multiple sensory neurons.
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关键词：
Animals Synapses Muscles Nerve Net Neurons Interneurons Motor Neurons Neuromuscular Junction Caenorhabditis elegans Microscopy, Electron
DOI：
10.1126/science.1221762
被引量：
年份：
2012
国家科技图书文献中心
(权威机构)
万方
万方医学
掌桥科研
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