Yang E, Korsmeyer SJMolecular thanatopsis: a discourse on the BCL-2 family. Blood 88: 386-401
摘要:
The maintenance of homoeostasis in normal tissues reflects a balance between cell proliferation and cell death. The importance of both positive and negative regulators of cell growth has been well documented in neoplasia. bcl-2 argues for the existence of a new category of oncogenes, regulators of programmed cell death. The bcl-2 gene was identified at the chromosomal breakpoint of t(14;18)...
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年份:
1996
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