Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors.
摘要：
Research on the specificities, functions, and maturation of T cells would be greatly aided by a collection of monoclonal antibodies which distinguishes different types of . With this end in mind were immunized and tested for production of pan-reactive anti-alpha beta antibodies. In this report we describe the properties and uses of a mAb, H57-597, produced from one of these . The mAb reacts with surface receptors on all alpha beta -bearing cells and does not react with receptors on gamma delta+ T cells. In an immobilized form, this antibody can directly activate T cells bearing alpha beta . It can be used in immunoprecipitation reactions to precipitate receptor from the appropriate cell types. In combination with anti-CD3, the antibody can be used in cytofluorographic analyses to measure numbers of CD3+, alpha , and CD3+, gamma delta+ cells in the thymus and periphery.
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DOI：
http://dx.doi.org/
被引量：
年份：
1989
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